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Which of the following is considered a negative risk factor for coronary artery disease?

  1. systolic blood pressure of 140mmHg

  2. body mass index of 28 kg/m2

  3. HDL cholesterol of 62 mg/dL

  4. LDL cholesterol of 120 mg/dL

The correct answer is: HDL cholesterol of 62 mg/dL

A HDL cholesterol level of 62 mg/dL is considered a negative risk factor for coronary artery disease because higher levels of HDL cholesterol are associated with a lower risk of developing heart disease. HDL, or high-density lipoprotein, is often referred to as "good" cholesterol because it helps transport cholesterol away from the arteries and back to the liver, where it can be processed and removed from the body. Higher levels of HDL cholesterol can help reduce the risk of coronary artery disease by preventing the buildup of plaque in the arteries, which is a contributing factor to heart disease. In contrast, the other options indicate conditions that are generally associated with an increased risk of coronary artery disease. For instance, a systolic blood pressure of 140 mmHg is considered high and can strain the heart and arteries. A body mass index (BMI) of 28 kg/m2 indicates overweight status, which is linked to various health issues, including heart disease. An LDL cholesterol level of 120 mg/dL is also considered borderline high and is associated with an increased risk of plaque buildup in the arteries. Thus, the other options do not contribute positively to cardiovascular health as HDL cholesterol does in this case.